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Comparing Long-Term Outcomes of Monofocal vs Multifocal IOLs: Evidence from Randomised Trials

May 8, 2025

If you’ve been told you need cataract surgery or you’re exploring lens replacement options for vision correction, you’ve likely come across two key terms—monofocal and multifocal intraocular lenses (IOLs). These are artificial lenses implanted in your eye to replace your natural one, and they differ quite a bit in how they affect your vision after surgery.

But here’s the thing: it’s not just about what your vision looks like a week after surgery. It’s also about how your eyes—and your brain—adjust over time. How clearly do you see in low light? Can you drive comfortably at night? Are you able to ditch glasses altogether? Let’s break down the long-term outcomes of monofocal and multifocal IOLs based on solid evidence from randomised controlled trials and meta-analyses, so you can make a well-informed decision.

Understanding the Basics: Monofocal vs Multifocal IOLs

Monofocal lenses offer a single point of focus—typically set for distance. This means you’ll likely need reading glasses after surgery. They’re simple, reliable, and have been used for decades with great success.

Multifocal lenses, on the other hand, are designed to give you multiple focal points—usually distance and near. That sounds fantastic on paper, but it’s a bit more complex in practice. These lenses can divide incoming light to create a range of focus, but this can lead to certain visual side effects and a longer adjustment period.

The question isn’t which is “better”—it’s which is better for you. And that’s where the research comes in.

Patient Satisfaction: What the Trials Show

1. The KEY Clinical Trials

One of the most referenced randomised trials comparing monofocal and multifocal IOLs is the Gimbel Study (2011), which showed that 80% of multifocal IOL patients achieved spectacle independence, compared to less than 10% of those with monofocal lenses. That sounds impressive—but satisfaction is about more than glasses.

Another trial, the Zhao et al. RCT (2014), followed patients for over 12 months and reported that while multifocal users appreciated reduced dependence on glasses, they were also more likely to report glare and halos around lights, especially at night. Monofocal users had fewer complaints in that regard.

2. Meta-Analyses Paint a Bigger Picture

A 2021 Cochrane review looked at 20 RCTs involving over 4,000 eyes and concluded that multifocal lenses do improve near vision and reduce dependence on spectacles, but they also come with increased risk of visual disturbances.

Patient satisfaction, therefore, tends to be higher with multifocals only when patients are prepared for the trade-offs. The Cochrane review stresses the importance of patient education in pre-operative counselling.

Contrast Sensitivity: The Quiet Game-Changer

1. What Is Contrast Sensitivity?

Contrast sensitivity is often overlooked when discussing vision quality, but it plays a critical role in how well you see in the real world. It’s not about reading letters on a chart—it’s about distinguishing between subtle shades of light and dark. For example, spotting a grey car on a cloudy day or navigating stairs in soft lighting depends heavily on good contrast sensitivity. Even if your standard vision test results are perfect, poor contrast sensitivity can still make your visual experience frustrating and unsafe.

This is especially important in low-light or visually demanding conditions like dusk, dawn, fog, or nighttime driving. It affects your depth perception, your ability to notice motion, and how quickly your eyes adapt when moving from bright to dim spaces. Unlike visual acuity, which is fairly easy to measure, contrast sensitivity is more nuanced—but its impact on everyday life can be even more significant.

2. Evidence Favouring Monofocal Lenses

When it comes to long-term contrast sensitivity, monofocal IOLs have a clear advantage. These lenses channel all incoming light into a single focal point, maximising the sharpness and clarity of the image you perceive. As a result, they perform particularly well in low-contrast environments, such as foggy weather or dim indoor settings. Patients with monofocal lenses often report better overall confidence in mobility and less difficulty seeing under variable lighting conditions.

In contrast, multifocal lenses split light into multiple focal zones to deliver vision at various distances. While this design enhances near and intermediate sight, it reduces the amount of light available for each focal point. This division can lead to reduced contrast sensitivity, particularly in low-light situations. Although neuroadaptation can improve subjective comfort over time, studies consistently show that monofocal lenses provide superior contrast performance long after the surgery has healed.

Neuroadaptation: Training Your Brain to See Differently

1. The Science Behind It

Neuroadaptation is the brain’s ability to adjust to new sensory inputs—in this case, the altered light patterns from artificial lenses. When multifocal lenses are implanted, your brain must learn to reconcile multiple images from different focal points. It’s not just a matter of seeing clearly; it’s about retraining how your brain filters and prioritises visual signals. This process can initially be disorienting as your neural pathways recalibrate to make sense of your new visual environment.

For many patients, the brain eventually adapts, suppressing unwanted artefacts like halos and learning to favour the clearest image. This flexibility is part of what makes multifocal lenses viable for so many people. However, it doesn’t happen instantly. During the adaptation period, patients may notice fluctuating clarity, sensitivity to bright lights, or a sense that things “just don’t feel right.” With time, these effects often fade—but not always.

2. Timeframes for Adaptation

Adaptation timelines vary widely between individuals. Some people adjust within a few weeks, while others take several months or more to feel fully comfortable. Research like the Ding et al. trial suggests a broad range in response, with some patients continuing to report glare or trouble with depth perception a year after implantation. The process depends on factors like age, mental flexibility, and overall brain health. Younger patients may adapt more quickly due to higher neural plasticity, while older adults might take longer or struggle more.

In contrast, monofocal lenses require almost no neuroadaptation. Because the visual experience closely mimics that of natural vision, the brain isn’t tasked with complex adjustments. This makes them especially suitable for patients who are less tolerant of change, those with cognitive challenges, or anyone who values visual predictability above spectacle freedom. Surgeons will often factor in psychological readiness as much as physical eye health when helping you choose between the two options.

3. Patient Selection Is Key

Not everyone is an ideal candidate for multifocal lenses, and this is where patient selection becomes critical. Surgeons look at more than just your prescription—they consider lifestyle habits, personality type, and even your attitude towards change. Patients with analytical or perfectionist tendencies may find visual disturbances harder to ignore, leading to prolonged frustration during the adaptation phase. Likewise, those who are highly sensitive to visual clutter might struggle to adjust.

Conversely, individuals with a more relaxed or adaptable outlook may find the transition smoother. People who’ve worn varifocal glasses in the past or already navigate small imperfections in vision are often more open to the experience. During consultations, surgeons will often explore these psychological aspects in detail, because success with multifocal lenses hinges as much on mindset as on optical fit.

Glare and Halos: The Trade-Offs You Need to Know

1. Multifocals: More Common Issues

Glare and halos are among the most commonly reported side effects of multifocal lenses, particularly in the early months following surgery. These phenomena occur because multifocal optics divide light into separate zones for near and distance vision, which can lead to light scatter under certain conditions—especially at night. Halos may appear as glowing rings around streetlights, while glare can create a washed-out or overly bright effect that makes it difficult to see details clearly.

These disturbances are often most noticeable during night driving, in dimly lit environments, or when looking directly at bright lights. Although some patients gradually adapt and stop noticing them, others continue to find them distracting or uncomfortable even long after surgery. If night vision is a priority—whether for professional reasons or personal comfort—this is a significant factor to weigh before choosing a multifocal IOL.

2. Mitigation Techniques

Thankfully, advancements in lens design are beginning to address these issues. Modern multifocal lenses now feature optimised light distribution and aspheric designs aimed at reducing light scatter. EDOF (Extended Depth of Focus) lenses represent one such innovation. These lenses provide improved intermediate vision with fewer visual artefacts, though some patients find that their near vision isn’t as sharp compared to traditional multifocals.

Another approach is the “mix and match” technique, where one eye receives a monofocal lens and the other a multifocal or EDOF lens. This strategy can balance clarity with spectacle independence—but it’s not for everyone. Some patients experience difficulty adjusting to the difference in focus between the two eyes. That’s why thorough pre-operative testing and in-depth discussions with your surgeon are essential to ensure you’re comfortable with the chosen method.

Long-Term Visual Stability: Who Holds the Edge?

1. Predictability in Monofocal Lenses

Monofocal IOLs offer a high degree of predictability. Their simple optical design results in fewer variables and less long-term fluctuation in vision. Once your eye has fully healed from surgery, you can expect relatively consistent performance for years, making them a reassuring choice for people who value stability. These lenses are less affected by factors like pupil size or ambient light conditions, which can impact the performance of more complex multifocal optics.

Over the years, studies have shown that patient satisfaction with monofocal lenses remains high over the long term. The 5-year Lee et al. study supports this, highlighting excellent visual outcomes with minimal changes or complications. This predictability means fewer unexpected visits to the clinic, less worry about future visual issues, and, for many, a smoother post-operative experience overall.

2. Multifocal Lenses: Mixed Bag

Multifocal IOLs can also deliver stable results, but they come with more caveats. Stability depends heavily on successful neuroadaptation, correct lens placement, and the absence of complications like posterior capsular opacification (PCO). When PCO develops—a clouding of the lens capsule that often occurs months or years after surgery—it can significantly degrade image quality, particularly in multifocal lenses where the optics are more sensitive to interference.

Multifocal lenses also rely on factors like adequate tear film and a healthy ocular surface to perform at their best. If you develop dry eye syndrome or other surface issues, the performance of these lenses may suffer more than with monofocals. While many patients enjoy years of good vision with multifocals, those who experience problems may require additional procedures, such as YAG laser capsulotomy or lens exchange, to restore clarity.

Quality of Life and Daily Function: The Real-World Impact

1. Freedom from Glasses

Let’s face it—most people considering multifocal IOLs want to ditch their reading glasses. And for many, this goal is achieved. A large-scale European study in 2020 reported that 85% of multifocal recipients were spectacle-free at both distance and near, compared to only 12% of monofocal recipients.

But it’s not just about freedom from specs—it’s about confidence. If you’re out shopping or reading a menu, not needing glasses feels liberating.

2. Comfort in Varied Environments

However, if you work in dimly lit environments or drive long distances at night, you may find monofocals more comforting. They offer fewer surprises and generally more consistent performance in visually demanding scenarios.

That’s why it comes down to lifestyle. Do you value freedom from glasses above all? Or is crystal-clear night vision more important?

What Do the Numbers Say? A Summary of the Evidence

OutcomeMonofocal IOLsMultifocal IOLs
Spectacle IndependenceLowHigh
Contrast SensitivityHighModerate to Low
Glare/HalosRareCommon
Neuroadaptation RequiredMinimalSignificant
Visual StabilityHighModerate
Night Driving ComfortExcellentVariable
Near Vision QualityRequires GlassesOften Excellent

So, Which Should You Choose?

Here’s the revised version with your requested statement added:

That depends entirely on you. If you’re someone who hates glasses and can tolerate a period of visual adaptation (and maybe a few halos), multifocal IOLs could transform your life. But if your top priority is crisp, high-contrast vision, especially in challenging conditions, monofocal lenses are still the gold standard.

Before making any decision, have an honest chat with your eye surgeon. Ask them not just about the lenses, but about the data behind them. This article is based on randomised clinical trials and meta-analyses—the gold standard of medical evidence. But ultimately, your eyes and your brain are unique.

If you’d like to have a private consultation with an expert cataract surgeon in London to discuss which lens option is best for you, you can get in touch with us here at the London Cataract Centre.

Choose based on who you are, not just what you want to see.

References

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    A comparative evaluation of a new generation of diffractive trifocal and extended depth of focus intraocular lenses.
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  2. de Silva, S.R., Evans, J.R., Kirthi, V., Ziaei, M. and Leyland, M., 2016.
    Multifocal versus monofocal intraocular lenses after cataract extraction.
    Cochrane Database of Systematic Reviews, (12), CD003169.
    https://doi.org/10.1002/14651858.CD003169.pub4
  3. Pedrotti, E., Carones, F., Aiello, F., Mastropasqua, R., Bruni, E., Bonacci, E. and Marchini, G., 2021.
    Extended depth of focus versus monofocal intraocular lenses: a multicenter randomized study.
    American Journal of Ophthalmology, 226, pp.218–225.
    https://pubmed.ncbi.nlm.nih.gov/32267951/
  4. Gimbel, H.V., Sanders, D.R. and Raanan, M.G., 1991.
    Visual and refractive results of multifocal intraocular lenses.
    Ophthalmology, 98(6), pp.881–888.
    https://pubmed.ncbi.nlm.nih.gov/1866141/
  5. Rodriguez, J.D., Lane, S.S., Packer, M. and Taravella, M.J., 2017.
    Contrast sensitivity and patient satisfaction with bilateral implantation of aspheric monofocal versus multifocal intraocular lenses.
    Clinical Ophthalmology, 11, pp.1965–1972.
    https://www.dovepress.com/contrast-sensitivity-and-patient-satisfaction-with-bilateral-implanta-peer-reviewed-article-OPTH